Dimethylsiloxane polymers for the effective transdermal delivery of Minoxidil in hair loss treatment.

ABSTRACT:

Purpose

Hair loss affects significant social and psychological well-being issues of the person. Thus, various drugs, ingredients, and technologies are being developed to overcome it. Minoxidil (MXD) is a representative hair loss treatment drug because it suppresses the production of dihydrotestosterone and induces vasodilation. However, since MXD has various side effects when used orally, it is more desirable to use it topically. In this work, we disclosed a new polymeric formulation (MXD@CP) based on citric acid (CA) dimethylsiloxane polymer (CP) for the effective transdermal delivery of MXD.

Methods

The polymer that induced ring-opening polymerization based on CA was named CA-siloxane polymer (CP). After CP synthesis, MXD was loaded onto CP to form MXD@CP. The formed MXD@C

SUBMITTER: Kim J 

PROVIDER: S-EPMC11871241 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature