Comparison of [¹⁸F]fluorodeoxyglucose and [⁶⁸Ga]Gallium DOTA-TATE in patients with active giant cell arteritis.

ABSTRACT:

Purpose

[¹⁸F]Fluorodeoxyglucose (FDG) is widely used in PET/CT imaging to detect large vessel vasculitis in giant cell arteritis (GCA), but its performance is suboptimal in patients receiving glucocorticoids. We aimed to compare [⁶⁸Ga]Ga-HA-DOTA-TATE, a somatostatin 2-analogue tracer, to [¹⁸F]FDG in a pilot study of patients with GCA.

Methods

Eight patients with active GCA were prospectively, sequentially scanned with both [¹⁸F]FDG PET/CT and [⁶⁸Ga]Ga-HA-DOTA-TATE PET/CT imaging. Images were evaluated by 2 blinded nuclear medicine specialists. Tracer uptake was assessed in 8 vascular territories using SUVmax, and target-background ratios (TBR) were calculated using both right atrium (TBR_RA) and liver mean (TBR

SUBMITTER: Clifford AH 

PROVIDER: S-EPMC11871265 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature