Best among the key molecular diagnostic markers of bacterial vaginosis.

ABSTRACT: To assess bacterial vaginosis (BV)-related primary molecular diagnostic markers of Lactobacillus crispatus, Gardnerella vaginalis, Fannyhessea vaginae, bacterial vaginosis-associated bacteria 2 (BVAB-2), Megasphaera-1 and Megasphaera-2 and to discover molecular diagnostic indicators of BV with the most economic value for the efficient diagnosis of BV.All vaginal secretion specimens, including 122 BV-positive cases and 130 BV-negative controls were collected. First, quantitative polymerase chain reaction (PCR) was used to determine the levels of above the six bacteria. Then, the detection rates, sensitivity, specificity, diagnostic threshold, and receiver operating characteristic (ROC) curve were compared. Megasphaera-1 and Megasphaera-2 were detected in the BV-positive group, with a low de

SUBMITTER: Deng T 

PROVIDER: S-EPMC11871275 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature