Microbiome analysis of gut microbiota in patients with colorectal polyps and healthy individuals.

ABSTRACT: Colorectal polyps serve as the primary precursors for colorectal cancer. A close relationship has been observed between colorectal polyps and gut microbiota. However, the composition and role of the microbiome associated with tubular adenoma are not well understood. In this study, we prospectively evaluated alterations in gut microbiota among patients with colorectal polyps. A total of 60 subjects were enrolled in this study, including 30 patients with colorectal polyps (CP group) and 30 healthy controls (control group). The 16S rRNA sequencing was employed to characterize the gut microbiome in fecal samples. The results revealed that the beta diversity of the gut microbiota in the CP group significantly differs from that of the control group (p = 0.001). At the phylum level, the relative

SUBMITTER: Deng D 

PROVIDER: S-EPMC11871317 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature