Feasibility and efficacy of the forced oscillation technique in patients with lysosomal storage diseases.

ABSTRACT: Lysosomal storage disorders (LSDs) are a diverse group of inborn errors of metabolism, which involves the storage of macromolecules within the lysosome due to the absence of or deficiency in lysosomal enzymes. In this condition, respiratory dysfunction is the common cause of morbidity and mortality. Thus, an objective measurement examination of pulmonary function, such as spirometry, is essential for the diagnosis and management of respiratory conditions. However, spirometry requires active patient involvement. Meanwhile, the forced oscillation technique (FOT) is performed during tidal breathing and is feasible in patients who cannot perform spirometry. Thus, the current study aimed to assess the feasibility and efficacy of FOT in assessing respiratory function among patients with LSD. Thi

SUBMITTER: Alblooshi A 

PROVIDER: S-EPMC11871331 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature