Pharmacological characteristics of once-weekly insulin icodec in Japanese individuals with type 1 diabetes.

ABSTRACT:

Introduction

Insulin icodec is a basal insulin designed for once-weekly administration. This study assessed the pharmacological properties of icodec in Japanese individuals with type 1 diabetes (T1D).

Materials and methods

In a randomized, open-label, crossover study, 24 Japanese individuals with T1D (20-64 years; glycated hemoglobin ≤9.0%) received once-weekly icodec for 8 weeks and once-daily insulin glargine U100 for 14 days at individual constant equimolar doses per week together with bolus insulin aspart. Individual doses were determined during run-in with glargine U100 titrated to prebreakfast self-measured plasma glucose (SMPG) of 4.4-7.2 mmol/L. Blood samples for icodec pharmacokinetics were taken from the first icodec dose until 35 days after last dose. The steady-s

SUBMITTER: Eto T 

PROVIDER: S-EPMC11871391 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature