Nonmotor Symptom Changes and Their Association With Falls Among Parkinson's Disease Patients Undergoing Deep Brain Stimulation: A 1-Year Cohort Study.

ABSTRACT:

Objectives

Fall severely affects the quality of life of Parkinson's disease (PD) patients. Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment for PD motor symptoms (MS), but DBS increased the risk of falls in some studies and has mixed effects on nonmotor symptoms (NMS). However, the link between NMS and falls, and how DBS influences this relationship, remain unclear. This study investigated changes in NMS and falls before and after STN-DBS, and the longitudinal association between NMS and falls.

Methods

The study included 136 PD patients undergoing STN-DBS between April 2020 and February 2022. Data were collected preoperatively, at 6 months, and at 12 months postoperatively. Assessments included MS via the Unified Parkinson's Disease Rating Sca

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11871399 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature