Utility of a Large Series of B-Cell Precursor Acute Lymphoblastic Leukemia Cell Lines as a Model System.

ABSTRACT:

Background

In B-cell precursor acute lymphoblastic leukemia (BCP-ALL), chromosomal translocations are strongly associated with prognoses. RNA sequencing (RNA-seq) is a powerful technology that reveals a close correlation between types of translocation and patterns of gene expression in clinical samples of BCP-ALL. Cancer cell lines are powerful research tools, and thus, we built a larger series of BCP-ALL cell lines and performed RNA-seq analysis to confirm their utility as a model system.

Methods

We performed RNA-seq in a total of 94 BCP-ALL cell lines, including 80 cell lines with 8 representative types of translocations.

Results

In the UMAP visualization, a close association was confirmed between the types of fusion genes and patterns of gene expression. In the clu

SUBMITTER: Tamai M 

PROVIDER: S-EPMC11871424 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature