Cerebral Blood Flow Changes and Their Spatial Correlations With GABAa and Dopamine-D1 Receptor Explaining Individual Differences in Chronic Insomnia and the Therapeutic Effects of Acupuncture.

ABSTRACT: This study integrated neuroimaging and neurochemistry data to explore brain mechanisms in chronic insomnia disorder (CID) and the neuromodulatory effects of acupuncture. We analyzed a cross-sectional arterial spin labeling (ASL) dataset (N = 197) of CID patients and healthy controls to identify cerebral blood flow (CBF) changes. Additionally, a longitudinal ASL dataset (N = 44) examined CBF changes in CID patients after a 4-week acupuncture treatment or on a waitlist. We then assessed the impact of 19 neurotransmitter receptors/transporters on these CBF alterations. In cross-sectional comparisons, CID patients exhibited increased CBF in cortical areas and decreased CBF in subcortical regions, correlating with insomnia severity. In longitudinal comparisons, acupuncture treatment enhanced su

SUBMITTER: Yu L 

PROVIDER: S-EPMC11871426 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature