Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia.

ABSTRACT:

Background

Alterations in the insulin-like growth factor (IGF) system have been reported for different tumours. They are of particular interest in the search for new prognostic and therapeutic approaches in cancer. In childhood acute lymphoblastic leukaemia (ALL) the amount of "tumour mass" at diagnosis can exceed 1 kg. To understand the endocrine, paracrine, and autocrine potential of the malignant transformed progenitor cells, the ability of these cells to express components of the IGF system needs to be investigated.

Aim

To characterise the expression pattern of genes of the IGF system in malignant lymphoblasts of children suffering from ALL.

Methods

Reverse transcription polymerase chain reaction of Ficoll separated mononuclear cells from 142 children with ALL, 12

SUBMITTER: Vorwerk P 

PROVIDER: S-EPMC1187145 | biostudies-literature | 2002 Feb

REPOSITORIES: biostudies-literature