Impact of BMPR2 mutation on the severity of pulmonary arterial hypertension: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the association between PAH severity in patients with and without BMPR2 mutation. Additionally, subgroup analyses were also performed to investigate whether differences existed among different ethnicities.

Methods

A literature search of the PubMed-MEDLINE, EMBASE, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials databases was conducted from inception through June, 2024, to identify eligible studies. Analyses were performed using Stata.

Results

Seventeen nonrandomized studies comprising a total of 2,190 patients were included in the analysis. Among the hemodynamic variables, the mPAP (WMD = 6.41, 95% CI: 5.07 ~ 7.76, P = 0.000), PVR (WMD = 3.66, 95% CI: 2.79 ~ 4.53, P = 0.000), CI (WMD=-0.38, 95% CI: -0.45 ~ -0.32, P = 0.

SUBMITTER: Wu J 

PROVIDER: S-EPMC11871596 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature