Intra- and peri-tumoral radiomics based on dynamic contrast-enhanced MRI for prediction of benign disease in BI-RADS 4 breast lesions: a multicentre study.

ABSTRACT:

Background and purpose

The study aimed to create a radiomics model based on breast intra- and peri-tumoral regions in dynamic contrast-enhanced (DCE) MRI to distinguish benign from malignant breast lesions of Breast Imaging Reporting and Data System (BI-RADS) 4.

Materials and methods

A total of 516 patients from Hospital 1 were assigned to the training cohort. Then, 146 and 52 patients were enrolled from Hospital 2 and 3, respectively, as the internal and external test cohort. Seven classification models were built, using features extracted from the intra- and peri-tumoral regions. Diagnostic performance was evaluated by receiver operating characteristics (ROC) analysis and compared by the DeLong test. Subgroup analysis was performed after stratifying all lesions by enhancem

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11871624 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature