M6A RNA methylation: a pivotal regulator of tumor immunity and a promising target for cancer immunotherapy.

ABSTRACT: M6A modification is one of the most common regulatory mechanisms of gene expression in eukaryotic cells, influencing processes such as RNA splicing, degradation, stability, and protein translation. Studies have shown that m6A methylation is closely associated with tumorigenesis and progression, and it plays a key regulatory role in tumor immune responses. m6A modification participates in regulating the differentiation and maturation of immune cells, as well as related anti-tumor immune responses. In the tumor microenvironment, m6A modification can also affect immune cell recruitment, activation, and polarization, thereby promoting or inhibiting tumor cell proliferation and metastasis, and reshaping the tumor immune microenvironment. In recent years, immunotherapies for tumors, such as immu

SUBMITTER: Chen X 

PROVIDER: S-EPMC11871626 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature