Proteomic analysis reveals the alleviation of follicular development defects in offspring mice under DEHP exposure by melatonin.

ABSTRACT:

Background

Environmental endocrine disruptor Di (2-ethylhexyl) phthalate (DEHP) widely affects the health of human and animals including the reproductive system. However, there are few studies on the protective strategies for the maternal DEHP exposure on follicular development of offspring. In the present study, we established a model of lactation female mice exposed to DEHP and reported the effects and potential mechanism of melatonin on the follicular development of offspring.

Results

Our data showed that melatonin rescued the decrease of primordial follicles, antral follicles and oocyte number (increased by 74.2%) of offspring caused by maternal DEHP exposure from the primordial follicle formation stage. Proteomic analysis showed that melatonin altered the ovarian steroi

SUBMITTER: Liu JC 

PROVIDER: S-EPMC11871628 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature