IRF1 is a core transcriptional regulatory circuitry member promoting AML progression by regulating lipid metabolism.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a prevalent malignancy of the hematologic system. Despite advancements in therapeutic approaches, significant heterogeneity and therapeutic resistance pose substantial challenges to treatment. Tumors driven by core transcription factors through super-enhancers can establish core transcriptional regulatory circuits (CRCs) that modulate oncogene expression programs. Identifying CRC is crucial for understanding disease-related transcriptional regulation. This study sought to predict and establish a CRC model for AML, identify genes critical for AML survival and explore their regulatory mechanisms in AML progression.

Methods

The dbCoRC tool was used for predictive analysis of H3K27ac ChIP-seq data from 11 AML samples to construct and va

SUBMITTER: Zhang F 

PROVIDER: S-EPMC11871635 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature