Impact of coronary artery calcium on progression of diastolic dysfunction: a cohort study.

ABSTRACT:

Background

The relationship between coronary artery calcium (CAC) and progression of diastolic dysfunction (DD) during longitudinal follow-up is uncertain. This study aimed to investigate the prevalence and progression of DD according to severity of CAC and understand their synergistic effect on mortality.

Methods

This was a population-based cohort study. All 15,193 adults who underwent a health screening exam with simultaneous echocardiography and CAC scan were enrolled. Definite DD (≥ 3/4 abnormal parameters for DD [e', E/e', tricuspid regurgitation velocity, and left atrial volume index]) and definite or probable DD (≥ 2/4) were defined. All-cause mortality was assessed based on the CAC and DD.

Results

Among the population, 7995 participants (52.6%) had CAC = 0; 46

SUBMITTER: Choi KH 

PROVIDER: S-EPMC11871669 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature