The impact of physical activity and intensity on clot mechanical microstructure and contraction in middle-aged/older habitual runners.

ABSTRACT:

Background

Exercise in healthy individuals is associated with a hypercoagulable phase, leading to a temporary increase in clot mass and strength, which are controlled by an effective fibrinolytic system. Conversely, people with cardiovascular diseases often have a reduced fibrinolytic pathway, increased clot mass and abnormal clot contraction, resulting in poorer outcomes. We assessed clot microstructure, particularly the contractile forces of clot formation, in response to two exercise intensities in middle-aged/older runners.

Methods

Twenty-eight habitual male and female runners aged over 40 years completed a 10 km moderate-intensity run; 14 of them performed a 3 km high-intensity run. Blood samples were collected at baseline, immediately postexercise and after 1 h of rest

SUBMITTER: Zaldua JC 

PROVIDER: S-EPMC11871672 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature