Donor age and breed determine mesenchymal stromal cell characteristics.

ABSTRACT:

Background

Mesenchymal stromal cells (MSCs) hold significant potential for various applications in regenerative medicine and tissue engineering. Initially considered as a single cell type with defined characteristics, MSCs are now known as a heterogeneous cell population with remarkable differences in their properties. No consensus exists on how donor age affects MSC characteristics, like proliferation. Additionally, differences in differentiation capacities and immunophenotype could arise when MSCs are isolated from different animals breeds, which is relevant for experimental and preclinical studies of MSC-based treatments.

Methods

In this study, we isolated bovine adipose tissue-derived MSCs from three age categories, i.e. fetal, calf, and adult, and of two different breed

SUBMITTER: Heyman E 

PROVIDER: S-EPMC11871689 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature