Effects of dietary supplementation of creatine on fetal development in gilts at d 60 and d 90 of gestation.

ABSTRACT:

Background

The creatine-creatine kinase-phosphocreatine (Cr-CK-PCr) system maintains intracellular ratios of ATP/ADP for support of cellular functions and has been characterized at the placental-uterine interface of rodents, primates, swine and sheep, and thus may support fetal development. This study determined effects of dietary supplementation of creatine (Cr) to gestating gilts on fetal development, the number and ratio of primary and secondary muscle fibers, and on protein expression in endometrium and fetal biceps-femoris muscle, respectively in fetal pigs on d 60 and d 90 of gestation.

Methods

Reproductively mature gilts were synchronized to estrus using Matrix, observed for estrus (d 0), and artificially inseminated 12 h and 36 h later. Gilts were individually housed

SUBMITTER: Lopez AN 

PROVIDER: S-EPMC11871691 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature