Diazepam exposure associated with an increased risk of acute kidney injury in children: an observational cohort study.

ABSTRACT:

Background

Potentially nephrotoxic drugs play an important role in acute kidney injury (AKI) in children. In the previous pharmacovigilance study, we found a statistical correlation between diazepam and AKI in children, but the causality needs to be further verified.

Methods

An observational cohort study was conducted to investigate the association between diazepam exposure and the risk of AKI in hospitalized children. The exposed group received diazepam while the control group did not. The outcome was AKI in accordance with the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Logistic regression was used to explore the association between diazepam exposure and the risk of AKI in children after adjusting for covariates.

Results

A total of 3018 hospitalized

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11871768 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature