Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states.

ABSTRACT:

Background

Rehabilitative training is an effective method to promote recovery following spinal cord injury (SCI), with lower training efficacy observed in the chronic stage. The increased training efficacy during the subacute period is associated with a shift towards a more adaptive or proreparative state induced by the SCI. A potential link is SCI-induced inflammation, which is elevated in the subacute period, and, as injection of lipopolysaccharide (LPS) alongside training improves recovery in chronic SCI, suggesting LPS could reopen a window of plasticity late after injury. Microglia may play a role in LPS-mediated plasticity as they react to LPS and are implicated in facilitating recovery following SCI. However, it is unknown how microglia change in response to LPS following SC

SUBMITTER: John RK 

PROVIDER: S-EPMC11871772 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature