Is ADC a rising star in solid tumor? An umbrella review of systematic reviews and meta-analyses.

ABSTRACT:

Background

Antibody-drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the potency of highly cytotoxic drugs and are known as panaceas, completely changing the treatment paradigm for solid tumors. Compared with other anti-cancer drugs, do they have better efficacy and lower toxicity risks? It is necessary to summarize and analyze the published clinical research data in this area to provide additional evidence-based evidence for clinical practice.

Objective

To comprehensively assess and overview the efficacy and safety of antibody-drug conjugates for the treatment of solid tumors.

Design

An umbrella review of systematic reviews and meta-analyses.

Methods

Systematic search of eight electronic databases and one registration platform inclu

SUBMITTER: Wei H 

PROVIDER: S-EPMC11871788 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature