Genetic insights into cardiac conduction disorders from genome-wide association studies.

ABSTRACT:

Background

Substantial data support a heritable basis for cardiac conduction disorders (CCDs), but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood, therefore, we sought to identify genetic loci associated with CCDs.

Methods

We performed meta-analyses of genome-wide association studies to identify genetic loci for atrioventricular block (AVB), left bundle branch block (LBBB), and right bundle branch block (RBBB) from public data from the UK Biobank and FinnGen consortium. We assessed evidence supporting the potential causal effects of candidate genes by analyzing relations between associated variants and cardiac gene expression, performing transcriptome-wide analyses, and ECG-wide phenome-wide associations for each indexed SNP.

SUBMITTER: Li B 

PROVIDER: S-EPMC11871809 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature