Comparative efficacy of different doses of platelet-rich plasma injection in the treatment of knee osteoarthritis: a systematic review and network meta-analysis.

ABSTRACT:

Background

Platelet-rich plasma (PRP) is increasingly used for knee osteoarthritis, but the optimal dosage still needs to be determined. This systematic review and network meta-analysis aimed to compare the efficacy of various PRP doses in treating knee osteoarthritis.

Methods

We searched published data in Embase, PubMed, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov, with no language restrictions from the inception to 30 September 2024. We enrolled randomized controlled trials (RCTs) that compared the clinical efficiency of different doses of PRP injection in patients with knee osteoarthritis. The outcomes were reduction in the Visual Analogue Scale (VAS) pain score or improvement of the total Western Ontario and McMaster Universities Osteoa

SUBMITTER: Khalilizad M 

PROVIDER: S-EPMC11871810 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature