Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma.

ABSTRACT:

Aims

Signalling through the Wnt pathway is integrally associated with colon carcinogenesis. Although activating mutations in the genes for adenomatous polyposis coli (APC) and beta-catenin are clearly associated with colon cancer, less is understood about the role of the upstream secreted ligands (Wnts) and their receptors (frizzled, Fz) in this process. In other systems, increased Wnt signalling has been shown to alter the expression of components of this pathway. This study was designed to test the hypothesis that colon cancer is characterised by aberrant expression of specific Wnt genes and Fz receptors.

Methods

The expression of Wnt genes was assessed by in situ, antisense RNA hybridisation in paraffin wax embedded samples of normal and malignant human colon tissues with

SUBMITTER: Holcombe RF 

PROVIDER: S-EPMC1187182 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature