Prenatal inflammation exacerbates hyperoxia-induced neonatal brain injury.

ABSTRACT:

Background

Premature born infants are at high risk to develop white matter injury (WMI). Hyperoxia and perinatal inflammation are main risk factors for preterm birth and associated brain injury. To date the majority of experimental studies have focused on isolated insults. However, clinically, WMI injury is a multifactorial disorder caused by a variety of triggers. To establish a clinically relevant rodent model of WMI, we combined prenatal inflammation with postnatal hyperoxia to investigate individual, and additive or synergistic effects on inflammatory processes, myelination and grey matter development.

Methods

At embryonic day 20, pregnant Wistar rat dams received either a single intraperitoneal injection of 100 µg/ kg lipopolysaccharide (LPS) or sodium chloride. Offspri

SUBMITTER: Serdar M 

PROVIDER: S-EPMC11871844 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature