Portulaca oleracea L. Methanolic Extract Protects the Brain of Male Rats Against Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) occurs as a result of a chronic neurodegenerative disorder that is most frequently linked to a decline in cognitive function and memory. Twenty-four male rats were divided into four groups (n = 6); Group I was the negative control, Group II was the AlCl₃-positive control, and Group III and Group IV were treated with 100 mg and 200 mg/kg of Portulaca oleracea methanolic extract, respectively. Aluminum chloride intoxication in Group II increased lipid peroxidation and decreased antioxidant parameters and affected interleukin-6 (IL-6), the tumor necrosis factor-alpha (TNF-α), acetylcholinesterase (AChE), and amyloid beta (Aβ), which lead to the induction of AD through injuring brain cells of AD rats. Treating the AD rats in Group III (GIII) an

SUBMITTER: El Rabey HA 

PROVIDER: S-EPMC11871972 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature