Apoptosis and cell cycle arrest of bone marrow cells by green-synthesized silver but not albumin nanoparticles.

ABSTRACT: Metallic nanoparticles (NPs) made by traditional means have a deleterious effect on bone marrow (BM) cells. Alternatively, green-synthesized NPs are cost-effective, ecofriendly, and may be less toxic. Also, albumin is a biocompatible blood protein involved in several physiological processes, employed in drug delivery without posing adverse effects, and is thought to be ideal NPs or coating for reducing the metallic NP's toxicity. We prepared albumin NPs (AlbNPs), biosynthesized silver NPs (AgNPs) using the metabolite of the Escherichia coli D8 strain and coated them with albumin (Ag/AlbNPs). These NPs were characterized and intraperitoneally administered to rats to compare their effect on rat BM cells. The flow cytometry results revealed that AgNPs significantly reduced viability, i

SUBMITTER: Eldabousy E 

PROVIDER: S-EPMC11872133 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature