X-chromosome-linked miR-542-5p as a key regulator of sex disparity in rats with adjuvant-induced arthritis by promoting Th17 differentiation.

ABSTRACT:

Background

Studies have indicated that X-linked microRNAs (miRNAs) play a role in the pathogenesis of rheumatoid arthritis (RA) and its gender-specific differences. However, research on specific miRNAs remains limited. This study aims to investigate the possible role of X-linked miR-542-5p in RA pathogenesis and gender differences.

Methods

We investigated the impact of miR-542-5p on RA pathogenesis and gender differences by manipulating its expression in various rat models.

Results

Our findings revealed a significant overexpression of miR-542-5p in RA patients compared with healthy individuals, with a notable gender difference among RA patients. In vivo experiments confirmed that upregulation of miR-542-5p could accelerate RA pathogenesis. Further analysis showed that

SUBMITTER: Yang JJ 

PROVIDER: S-EPMC11872315 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature