Evaluation of uNGAL and TIMP-2*IGFBP7 as early biomarkers of Acute Kidney Injury in Caucasian term and preterm neonates: a prospective observational cohort study.

ABSTRACT:

Background

Early diagnosis of Acute Kidney Injury (AKI) in neonates is a complex challenge. Novel urinary biomarkers such as uNGAL and TIMP-2*IGFBP7 may be helpful for predicting AKI earlier than changes in serum creatinine (sCr) and urinary output (UOP) in the neonatal period. uNGAL is a marker of tubular injury and its concentration rises immediately after AKI, while the proteins TIMP-2 and IGFBP7 jointly participate in the G1 phase cell cycle arrest processes and their tubular expression and urinary excretion increase in response to kidney damage. The aim of this study is to determine urinary concentrations of uNGAL and TIMP-2*IGFBP7 in term and preterm newborns and to evaluate their predictive role of AKI.

Methods

Forty-two heathy term neonates and twenty-six preterm inf

SUBMITTER: Panza R 

PROVIDER: S-EPMC11872328 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature