Epicutaneous immunotherapy for food allergy: A systematic review and meta-analysis.

ABSTRACT:

Background

Food allergies pose a global healthcare challenge, underscoring the need for effective interventions. This study evaluated the efficacy and safety of epicutaneous immunotherapy (EPIT) for food allergen desensitisation.

Methods

We conducted a systematic review of randomised controlled trials by searching Ovid EMBASE, PubMed and Scopus in April 2024. Using a random-effects meta-analysis, we evaluated the clinical effectiveness and harms of EPIT, reporting results as risk ratios with 95% confidence intervals (CI).

Results

After screening 460 abstracts and 35 full reports, 11 were included: nine on peanuts and two on cow's milk (CM). Peanut EPIT had a 51.2% treatment response versus 22.4% for placebo (RR 2.16, CI 1.49-3.12; four studies; moderate certainty). Th

SUBMITTER: Csonka P 

PROVIDER: S-EPMC11872371 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature