Cerebral blood flow and cognitive functioning in patients undergoing transcatheter aortic valve implantation.

ABSTRACT:

Background

Approximately one-third of patients with symptomatic severe aortic valve stenosis scheduled for transcatheter aortic valve implantation (TAVI) have some degree of cognitive impairment. The effect of TAVI on cardiac output, cerebral blood flow (CBF), and cognitive functioning has not been systematically studied.

Methods

CAPITA (NCT05481008) is a prospective longitudinal study assessing cerebral and cognitive outcomes in patients that underwent TAVI between August 2020 and October 2022. At baseline (<24 h before TAVI) and three-month follow-up, patients underwent echocardiography, brain magnetic resonance imaging (MRI), and multidomain neuropsychological assessment. Primary outcome measures were change in CBF (Δml/100 g/min on arterial spin labelling MRI) and change

SUBMITTER: van Nieuwkerk AC 

PROVIDER: S-EPMC11872408 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature