NFAT single-deficient murine T cells reduce the risk of aGvHD while controlling cytomegalovirus infection.

ABSTRACT: NFAT is a family of transcription factors whose activation is inhibited by calcineurin inhibitors (CNIs). In allogeneic hematopoietic stem cell transplantation (allo-HCT), CNIs are employed to prevent and treat graft-versus-host disease (GvHD). Unfortunately, control of cytomegalovirus (CMV), which exacerbates clinical outcomes, is simultaneously lost. Since single NFAT deficiency in T cells ameliorates GvHD in our major mismatch model, we investigated whether protection is maintained during CMV infection. Reassuringly, NFAT-deficient T cells still improved GvHD upon acute CMV infection and after allo-HCT in latently CMV-infected mice, showing reduced proinflammatory and cytotoxic potential. In sharp contrast, CMV-specific NFAT-deficient CD8⁺ inflated memory T cells expanded mor

SUBMITTER: Hundhausen N 

PROVIDER: S-EPMC11872454 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature