Characterization of severity of hemolytic disease of the fetus and newborn due to Rhesus antigen alloimmunization.

ABSTRACT:

Background

Clinical manifestations of hemolytic disease of the fetus and newborn include anemia, hyperbilirubinemia, hydrops fetalis, kernicterus, and fetal or neonatal demise. More than 50 antibodies are linked to hemolytic disease of the fetus and newborn, with Rhesus (including D and c) and Kell antigens carrying the highest risk of disease. To date, a multicenter, comprehensive evaluation of hemolytic disease of the fetus and newborn due to Rhesus antigen alloantibodies in the United States has not been undertaken.

Objective

This study aimed to implement a novel severity index to characterize the real-world disease spectrum of hemolytic disease of the fetus and newborn due to alloantibodies from the Rhesus class.

Study design

This retrospective cohort study was co

SUBMITTER: Krumme AA 

PROVIDER: S-EPMC11872512 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature