Sedentary Leisure Behaviour, Physical Activity, and Gastroesophageal Reflux Disease: Evidence From a Mendelian Randomization Analysis.

ABSTRACT:

Background and aims

Gastroesophageal reflux disease (GERD) is common worldwide. Although associations between sedentary behaviour (LSBs), physical activity (PAs), and GERD have been reported, their causal relationships remain unclear. This study uses Mendelian randomization (MR) to examine these associations with GERD.

Methods

Genetic instruments from the UK Biobank and other consortia were utilized to assess the causal relationship between LSBs, PAs, and GERD. Causal analyses employed inverse variance weighted (IVW), weighted-median (WM), and MR-Egger regression. Sensitivity analyses included Cochran's Q test, MR-Egger intercept test, leave-one-out analysis, and funnel plot assessment. Outliers were detected using MR-PRESSO and Radial MR. A risk factor analysis explo

SUBMITTER: Lu S 

PROVIDER: S-EPMC11872599 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature