Toxicities Associated with Adjuvant Radiation Therapy in Atypical Meningioma.

ABSTRACT:

Purpose

While adjuvant radiation therapy (RT) may prolong progression-free survival in resected atypical meningiomas, whether such progression-free survival benefit outweighs potential treatment toxicities remains controversial. Here, we compare the acute and late toxicity outcomes of atypical meningiomas managed with upfront adjuvant RT versus surveillance.

Methods and materials

In our prior single-institution retrospective study of 230 patients with resected atypical meningiomas between 2000 and 2015, adjuvant RT was associated with a significantly lower risk of progression/recurrence compared with surveillance (hazard ratio, 0.21; P < .01), with 36% of surveillance patients eventually requiring salvage RT. In this study, the acute (≤6 months) and late (>6 months) R

SUBMITTER: Lee G 

PROVIDER: S-EPMC11872651 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature