<i>Bacillus pumilus 315</i> improves intestinal microbiota and barrier function to alleviate diarrhea of neonatal goats.

ABSTRACT: Diarrhea is the leading cause of mortality in postnatal goat kids, seriously impacting breeding efficiency. This study aimed to explore the effects of Bacillus pumilus 315 (B. pumilus) on goat kids' diarrhea and its regulatory mechanism. Thirty-six 1-day-old goat kids were assigned into four treatments, the control (CON) group and low-, medium- and high-dose groups supplemented with B. pumilus at 1 × 10⁸ (BP1), 5 × 10⁸ (BP5), and 1 × 10⁹ CFU/d (BP10). Each group consisted of 9 replicates with 1 goat kid per replicate. The results showed that the incidence of diarrhea and fecal scores decreased significantly (P < 0.05). A dose of 5 × 10⁸ CFU/d B. pumilus reduced pro-inflammatory factors (including tumor necrosis

SUBMITTER: Fan D 

PROVIDER: S-EPMC11872662 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature