Increased proline intake during gestation alleviates obesity-related impaired fetal development and placental function in gilts.

ABSTRACT: Maternal proline (Pro) supplementation enhances fetal survival and placental development in mice. However, the effect of Pro on fetal and placental development in gilts remains to be investigated, particularly in the context of obesity-induced impaired pregnancy. Here, we investigated the effect of dietary Pro on fetal and placental development in obese gilts. Exp.1: On day 60 of gestation, 48 gilts with similar delivery times were selected and followed up until delivery to determine the relationship between maternal obesity, litter performance, and Pro abundance in term placentae. The results showed that impaired reproductive performance was associated with body condition parameters and inadequate placental Pro availability of gilts. Exp. 2: A total of 114 gilts were then used in a 2 × 3

SUBMITTER: Huang S 

PROVIDER: S-EPMC11872664 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature