Maternal dietary inulin intake during late gestation and lactation ameliorates intestinal oxidative stress in piglets with the involvements of gut microbiota and bile acids metabolism.

ABSTRACT: Maternal inulin intake has been shown to alleviate oxidative stress in piglets, but the role of bile acids (BAs) in this process remains unknown. This study aimed to investigate the roles of gut microbiota and BAs metabolism in the amelioration of intestinal oxidative stress in piglets through a maternal inulin diet. A total of 40 sows were allocated into two dietary treatments from day 85 of gestation until the end of lactation: CON (control diet) and INU (diet with 2% wheat bran replaced by inulin). An oxidative model was further established on the intestinal porcine epithelial cell-jejunum 2 cell line (IPEC-J2) to examine the effect of bacterial BAs on intestinal oxidative stress. Results showed that the maternal inulin diet promoted the average daily gain of piglets during suckling and

SUBMITTER: Lu D 

PROVIDER: S-EPMC11872665 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature