The Use of Caffeine Citrate in the Management of Neonatal Apnea in Low- and Middle-Income Countries: A Rapid Systematic Review.

ABSTRACT:

Background and aims

Caffeine citrate is an example of a methylxanthine approved for managing apnea of prematurity (AOP). However, there is limited evidence of its use in low- and middle-income countries (LMICs). This rapid systematic review aims to appraise the literature on using caffeine citrate in managing neonatal apnea in LMICs.

Methods

A comprehensive search was conducted on literature reporting the treatment of AOP in LMICs. The search was based on a population, intervention, comparison, and outcome format using medical subject heading terms. The PRISMA and PRISMA extension for scoping reviews guidelines were meticulously followed. PubMed, Science Direct, and Scopus were among the bibliographic databases searched. Initially, 2638 articles were identified based on the

SUBMITTER: Amponsah SK 

PROVIDER: S-EPMC11872687 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature