Association Between Depression and Lung Cancer Risk Among Postmenopausal Women.

ABSTRACT:

Background

In recent years, the association between depression and various chronic diseases has attracted widespread attention. However, the effect of depression on lung cancer incidence has not been well studied. This study aimed to explore whether depression increases the incidence of lung cancer and to analyze the mediating and moderating roles of smoking in this relationship.

Methods

This study used large-scale longitudinal data sourced from the Women's Health Initiative, encompassing 123,961 postmenopausal women. Depressive symptoms were measured using the 8-item Burnam regression algorithm with a cut-point of 0.06, and depression was defined as either depressive symptoms or antidepressant use at baseline. The relationship between depression and lung cancer incidence wa

SUBMITTER: La Y 

PROVIDER: S-EPMC11872688 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature