NOD1, NOD2, PYDC1, and PYDC2 gene polymorphisms in ovarian endometriosis.

ABSTRACT:

Background

Endometriosis, a prevalent chronic gynecologic disorder, significantly impacts women's health, with both genetic and environmental factors contributing to its heritability. Within the adaptive immune system, the NOD-like receptors (NLR) pathway plays pivotal roles in various autoinflammatory diseases, regulating interleukins, proinflammatory cytokines, and NF-κB activity. However, the potential association between single nucleotide polymorphisms (SNPs) of the NOD1, NOD2, PYDC1, and PYDC2 genes and the predisposition to endometriosis risk remains unexplored.

Methods

In this cross-sectional study, 54 patients diagnosed with ovarian endometriosis and 54 control subjects were included. The genetic SNPs of NOD1 (rs2075820 and rs2075818) and NOD2 (rs104895461) were asse

SUBMITTER: Kula H 

PROVIDER: S-EPMC11872704 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature