Single-cell dual-omics reveals translational and transcriptional landscapes and regulations in oocytes from ovarian endometriosis patients.

ABSTRACT:

Introduction

A significant proportion of women in their reproductive years are afflicted by endometriosis. And one of the major contributing factors to infertility linked to ovarian endometriosis is thought to be oocyte quality. The precise molecular mechanisms are still unknown. Furthermore, because of transcriptional silence, translatome is better able to explain molecular behavior in oocytes than transcriptome sequencing, which has been used widely in recent years.

Methods

We conducted single-cell transcriptome and translatome sequencing on oocytes obtained from patients with ovarian endometriosis, as well as from control subjects with infertility due to tubal or male factors.

Results

For the first time, we characterized the translational and transcriptional profil

SUBMITTER: Diao X 

PROVIDER: S-EPMC11872718 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature