Microvascular disease and severe COVID-19 outcomes in UKBiobank participants with diabetes.

ABSTRACT:

Aims

Early in the COVID-19 pandemic, evidence emerged suggesting that people with diabetic retinopathy (DR) or other microvascular diseases had greater risk of severe short-term outcomes. This study evaluated longer-term outcomes, providing more generalisable evidence.

Methods

We identified a cohort of UKBiobank participants with diabetes and retrieved their diagnostic codes for a variety of microvascular diseases, complications of diabetes and systemic comorbidities. We investigated relationships between diagnoses and the study outcome: admission to Critical Care or death from COVID-19, taking age, sex and diabetes duration into account. We tested relationships, adding baseline covariates and weighting diagnostic codes according to their recency prior to COVID-19 diagnosis.

SUBMITTER: Tochel C 

PROVIDER: S-EPMC11872747 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature