Early onset sleep disorders predict severity, progression and death in multiple system atrophy.

ABSTRACT:

Background

Early stridor onset (≤ 3 years from disease onset) is a predictor of shorter survival in Multiple System Atrophy (MSA), but its role on disease progression is not yet established. In MSA, previous studies on trajectories of disease did not include stridor and REM sleep behavior disorder (RBD) as clinical variable. The aims of the study were: (1) to investigate disease progression in MSA patients with early stridor onset and with early stridor and/or RBD onset; (2) to assess cerebrospinal fluid (CSF) levels of neurofilament light chain protein (NfL) in MSA patients with early onset sleep disorders.

Methods

This is a retrospective and prospective cohort study including 208 (120 males) MSA patients. Occurrence of symptoms/signs, milestones of disease progression, and

SUBMITTER: Giannini G 

PROVIDER: S-EPMC11872749 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature