Subcellular localization of SARS-CoV-2 E and 3a proteins along the secretory pathway.

ABSTRACT: SARS-CoV-2 E and 3a proteins are important for the assembly, budding, and release of viral particles. These two transmembrane proteins have been implicated in forming channels in the membrane that allow the transport of ions to favor viral replication. During an active infection, both proteins generally localize to the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and the Golgi where viral assembly occurs. The ER and Golgi are critical for the proper packaging and trafficking of cellular proteins along the secretory pathways which determine a protein's final destination inside or outside of the cell. The SARS-CoV-2 virus primarily infects epithelial cells that are highly secretory in nature such as those in the lung and gut. Here we quantified the distribution of S

SUBMITTER: Hinkle JJ 

PROVIDER: S-EPMC11872775 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature