DEAD-box RNA helicase DDX-23 mediates dietary restriction induced health span in Caenorhabditis elegans.

ABSTRACT: Dietary restriction (DR) extends lifespan in diverse species, from yeast to mammals. However, its underlying mechanisms are not well understood. In this study, through using the tractable model Caenorhabditis elegans, we show a role for the DEAD-box RNA helicase, DDX-23 (homologous to mammal DDX23) as a regulator of healthspan in response to dietary restriction. Meanwhile, DDX-23 is also required for heat and oxidative stress response in C. elegans. Intriguingly, DDX-23 functions in the germline during adult to regulate dietary restriction-induced longevity. We then find that PHA-4/FOXA acts downstream of DDX-23 to mediate the transcriptional response of SOD-related genes and consequently the lifespan of the animals. Furthermore, we find that the DEAD-box RNA helicase, DDX-23 negatively re

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC11872819 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature