What is normal age-related thigh muscle composition among 45- to 84-year-old adults from the UK Biobank study.

ABSTRACT: A loss of skeletal muscle mass and an increase in intramuscular fat are known to occur as we enter middle and older age, but the expected changes or normative values have remained unknown. The primary reason for this is that imaging studies are difficult and expensive to conduct, and consequently, the sample sizes have remained small. The development of the UK Biobank which provides access to a large magnetic resonance imaging (MRI) data set of more than 50,000 participants provides an opportunity to finally address this question of normative values for each age group. The study's primary aim was to determine the age-related changes in thigh muscle composition (e.g., thigh fat-free muscle volume and intramuscular fat) between the ages of 45 and 84 years. The second aim was to analyse assoc

SUBMITTER: Anderson DB 

PROVIDER: S-EPMC11872857 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature