The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives.

ABSTRACT: The COVID-19 pandemic has left a lasting legacy on human health, extending beyond the acute phase of infection. This article explores the evidence suggesting that SARS-CoV-2 infection can induce persistent epigenetic modifications, particularly in DNA methylation patterns, with potential long-term consequences for individuals' health and aging trajectories. The review discusses the potential of DNA methylation-based biomarkers, such as epigenetic clocks, to identify individuals at risk for accelerated aging and tailor personalized interventions. Integrating epigenetic clock analysis into clinical management could mark a new era of personalized treatment for COVID-19, possibly helping clinicians to understand patient susceptibility to severe outcomes and establish preventive strategies. Sev

SUBMITTER: Gaetano C 

PROVIDER: S-EPMC11872859 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature