No association between markers of systemic inflammation and endothelial dysfunction with Alzheimer's disease progression: a longitudinal study.

ABSTRACT:

Introduction

Systemic inflammation and endothelial dysfunction are potentially modifiable factors implicated in Alzheimer's disease (AD), which offer potential therapeutic targets to slow disease progression.

Methods

We investigated the relationship between baseline circulating levels of inflammatory (TNF-α, IL-1ß) and endothelial cell markers (VCAM-1, ICAM-1, E-selectin) and 18-month cognitive decline (ADAS-cog12) in 266 mild-to-moderate AD patients from the NILVAD study. We employed individual growth models to examine associations, potential mediation, and interaction effects while adjusting for confounders.

Results

The average increase in ADAS-cog12 scores over all patients was 8.1 points in 18 months. No significant association was found between the markers and th

SUBMITTER: van Setten A 

PROVIDER: S-EPMC11872860 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature